Thermo Fisher Scientific JMJD1C Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Target Information

The jumonji domain containing 1C protein (JMJD1C) was initially discovered in silico and later suggested to be a candidate gene for autism. Like the related proteins JMJD1A and JMJD1B, JMJD1C is a histone H3K9 demethylase implicated in nuclear hormone receptor-based transcriptional regulation.
JMJD1C mRNA is highly expressed in undifferentiated embryonic stem (ES) cells, pancreatic islet, diffuse-type gastric cancer, and other tissues and tumors. The JMJD1C gene promoter contains bHLH-, AP-1-, and POU5F1-binding sites. Preferential expression of POU5F1 in ES cells, pancreatic islet, and diffuse-type gastric cancer suggests that POU5F1-mediated expression of JMJD1C reactivates previously silenced genes in these tissues.
At least three isoforms of JMJD1C are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.