Thermo Fisher Scientific Calpain 6 Polyclonal Antibody
Calpain 6 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Western blot 및 Immunocytochemistry에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS buffer와 glycerol로 안정화되어 있습니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA583496
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CAPN6. Recombinant protein control fragment (Product # RP-98332) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2790649 |
Product Specific Information
Immunogen sequence:
TLDMPKMSCW NLARGYPKVV TQITVHSAED LEKKYANETV NPYLVIKCGK EEVRSPVQKN TVHAIFDTQA IFYRRTTDIP IIVQVWNSRK FCDQFLGQ
Target Information
Calpain-6 (also known as calpamodulin or calpain-X) is an intracellular, calcium-dependent cysteine protease. Unlike the ubiquitous calpain-1 and calpain-2, calpain-6 exhibits tissue-specific expression, primarily in the placenta, though it is expressed embryonically in various tissues.
The classical calpain family consists of a small common subunit (calpain-4) and a large variable subunit. It is unclear whether calpain-6 associates with a small subunit. The large subunit includes domain-I (amino terminal), domain-II (proteinase), domain-III, and domain-IV (EF-hand domain, or domain T in calpains 5 and 6).
Calpain-6, located on the X chromosome, lacks the EF-hand calcium-binding motif found in classical calpains. Additionally, its canonical active site residues (Cys, His, Asn) are replaced by Lys, His, Asn in humans and Lys, Tyr, Asn in mice, suggesting that calpain-6 is likely proteolytically inactive.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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