Thermo Fisher Scientific GCP5 Polyclonal Antibody

Applications

• Immunocytochemistry (ICC/IF): 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
SLYTLFLESV QSRLRHGEDS TPQVLTEQQA TKENLMKMQS IAESHLELDD VHDPLLAINF ARMYLEQSDF HEKFAGGDVC VDRSSESVTC QTFELTLRSC

Target Information

The gamma-Tubulin complex is composed of gamma Tubulin and the gamma-Tubulin complex associated proteins GCP2, GCP3, GCP4, GCP5, and GCP6, all of which are essential components of microtubule organizing centers.
These components localize to both the centrosome, where they participate in microtubule nucleation, and to the cytoplasm, where they exist as soluble complexes that can be recruited to the centrosome as needed.
Although the GCP proteins are related, they have distinct roles contributing to the proper function of the gamma-Tubulin complex.
GCP5 (gamma-Tubulin complex component 5), also known as TUBGCP5, is a 1,024 amino acid member of the gamma-Tubulin complex and is highly expressed in heart and skeletal muscle.
Defects in the gene encoding GCP5 are implicated in Prader-Willi syndrome (PWS), a rare genetic disorder associated with obesity, compulsive behavior, and lower intellectual ability.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.