Thermo Fisher Scientific TNPO3 Recombinant Rabbit Monoclonal Antibody (JG38-77)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

1:50-1:200

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

JG38-77

Immunogen

Recombinant protein within Human TNPO3 aa 830-923 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TNPO3,uniProtId:Q9Y5L0-2,ncbiNodeId:9606,antigenRange:830-923,antigenLength:923,antigenImageFileName:MA5-34790_TNPO3_Q9Y5L0-2_Rabbit.svg,antigenImageFileNamePDP:MA5-34790_TNPO3_Q9Y5L0-2_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 40% glycerol, 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles, store in dark

Shipping conditions

Wet ice

RRID

AB_2848698

Product Specific Information

Positive Control: HL-60, mouse pancreas tissue lysate, A549, SH-SY-5Y, SiHa, human liver cancer tissue, human small intestine tissue, mouse lung tissue, mouse kidney tissue.

Target Information

TNPO3 is a member of the importin beta/transportin family of nuclear import receptors and is specific for the essential splicing factors termed SR proteins, binding specifically and directly to the arginine/serine (RS)-rich domains of these proteins. Further experiments demonstrated that this interaction occurs only when these RS domains are phosphorylated. More recently, TNPO3 was identified as an HIV dependency factor (HDF) and that depletion of TNPO3 resulted in HIV inhibition after reverse transcription but before integration, suggesting that TNPO3 may be an important drug target in HIV treatment. At least three isoforms of TNPO3 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.