Thermo Fisher Scientific Phospho-CHK2 (Ser19) Polyclonal Antibody
CHK2 단백질의 Ser19 인산화를 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC, ELISA 등 다양한 응용에 적합합니다. DNA 손상 반응 및 종양 억제 단백질 연구에 유용하며, 고순도 Protein A 정제 제품입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human CHK2 around the phosphorylation site of Ser19 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CHEK2 (CHK2) is a serine/threonine kinase involved in the DNA damage checkpoint pathway. Mutations in CHK2 have been associated with various cancers. Upon DNA damage, CHK2 is activated and phosphorylates several cell cycle regulators, including tumor suppressor proteins such as BRCA1, aiding in cell survival after DNA damage. CHK2 functions as a tumor suppressor, with mutations linked to Li-Fraumeni syndrome, sarcomas, breast cancer, and brain tumors.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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