Thermo Fisher Scientific NF Monoclonal Antibody (OTI3F7), TrueMAB
인간 신경필라멘트 단백질(NFH, NEFM, NEFL)에 반응하는 Mouse IgG1 단클론 항체. Western blot 및 IHC(P) 검증 완료. 동결건조 형태로 제공되며, 재구성 후 1 mg/mL 농도. 연구용으로만 사용 가능.
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Thermo Fisher Scientific NF Monoclonal Antibody (OTI3F7), TrueMAB
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3F7 |
| Immunogen | Synthetic peptide corresponding to the conserved region of human neurofilament heavy polypeptide (NEFH), medium polypeptide (NEFM) and light polypeptide (NF68, NEFL) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Synthetic peptide sequence: EYQDLLNVKMALDIEIAAYRKLLEGEE
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. They form the axoskeleton and maintain neuronal caliber, playing roles in intracellular transport to axons and dendrites.
The encoded medium neurofilament protein is a biomarker of neuronal damage.
Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Associated Diseases:
- Pineal Parenchymal Tumor of Intermediate Differentiation
- Wallerian Degeneration
Related Pathways:
- Amyotrophic Lateral Sclerosis (ALS)
- Neural Stem Cell Differentiation Pathways and Lineage-specific Markers
Gene Ontology (GO):
- Structural molecule activity
- Structural constituent of cytoskeleton
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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