Thermo Fisher Scientific MKNK2 Polyclonal Antibody
Thermo Fisher Scientific의 MKNK2 폴리클로날 항체는 인간 및 생쥐 시료에서 MKNK2 단백질 검출에 적합합니다. Western blot에 1:1,000 희석으로 사용 가능하며, KLH 결합 합성 펩타이드로 면역화되었습니다. 고순도 정제 및 안정적 보관 조건을 제공합니다.
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Applications
- Western Blot (WB): Tested Dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 70–100 amino acids from the N-terminal region of human MNK2 (MKNK2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Ammonium sulfate precipitation, Size-exclusion, Dialysis |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2142785 |
Product Specific Information
This antibody is predicted to react with mouse and rat based on sequence homology.
Target Information
The MAP kinase-interacting kinases (MKNK1 and MKNK2) are activated by MAP kinases and regulate protein synthesis by phosphorylating eIF4E on Ser209, potentially contributing to tumorigenesis. Overexpression of Mnk2 increases phosphorylation of endogenous eIF-4E, indicating its role as an eIF-4E kinase in vivo. Mnk2 may also be involved in cellular responses to environmental stress and cytokines. Active mutants of MNK1 and MNK2 expressed in 293 cells reduce cap-dependent translation relative to cap-independent translation. Human Mnk2 shares ~94% identity with murine Mnk2 and ~71% with human Mnk1. In vitro, Mnk2 is a better substrate than Mnk1 for Erk2, p38MAPKα, and p38MAPKβ.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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