Thermo Fisher Scientific YTHDF1 Polyclonal Antibody
YTHDF1 단백질을 검출하는 Thermo Fisher Scientific의 폴리클로날 항체입니다. WB 및 ICC/IF에 적합하며, 인간·마우스·랫트 반응성을 보입니다. 액상 형태, 1 mg/mL 농도로 제공되며, -20°C에서 보관합니다. m6A 포함 mRNA와 결합하여 번역 효율을 조절합니다.
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- PA5101252
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- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human YTHDF1 (Accession Q9BYJ9), corresponding to amino acid residues M1–Y37 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850691 |
Product Specific Information
Antibody detects endogenous levels of total YTHDF1.
Target Information
YTHDF1 specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting mRNA translation efficiency (PubMed:24284625, 26046440, 26318451).
m6A modification affects mRNA splicing, processing, and stability. YTHDF1 enhances ribosome loading on m6A-containing mRNAs and interacts with translation initiation factors eIF3 (EIF3A or EIF3B).
It contributes to learning and memory formation in the hippocampus by promoting translation of neuronal mRNAs upon stimulation.
Additionally, it regulates axon guidance via ROBO3 transcripts and negatively regulates antigen cross-presentation in myeloid dendritic cells, influencing tumor immune response.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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