Thermo Fisher Scientific TIN2 Polyclonal Antibody
인간 TIN2 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체. Western blot과 ICC/IF에 사용 가능. 고순도 친화 크로마토그래피 정제, PBS/glycerol 용액 형태로 제공. -20°C 보관, 연구용 전용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TINF2 (Accession Q9BSI4), corresponding to amino acid residues R74–A124 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850688 |
Product Specific Information
Antibody detects endogenous levels of total TINF2.
Target Information
TRF1 is a negative regulator of telomere length maintenance. Two proteins, tankyrase and Tin2, which bind to mammalian TRF1, have been identified.
Tankyrase localizes to telomeres by binding to TRF1 through its ankyrin repeats and exhibits PARP activity functioning as acceptors for ADP-ribosylation.
ADP-ribosylation of TRF1 diminishes its ability to bind to telomeric DNA, suggesting telomere function in human cells is regulated by poly (ADP)-ribosylation.
TIN2 was isolated as an interacting partner of TRF1 from a yeast two-hybrid cDNA library screening. Tin2 localizes to telomeres and is essential for proper regulation of telomere length.
TIN2, like TRF1, is widely and constitutively expressed, suggesting cooperative action to counterbalance telomere elongation by telomerase.
However, endogenous TIN2 is not highly expressed and may be difficult to visualize by immunostaining in certain cell systems.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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