Thermo Fisher Scientific Aminoacylase Monoclonal Antibody (OTI2D3)
Thermo Fisher Scientific의 Aminoacylase 단클론 항체(OTI2D3)는 Western blot, IHC, Flow cytometry에 사용 가능하며 인간, 마우스, 랫트, 개에 반응합니다. HEK293 세포에서 생산된 전체 길이 인간 ACY1 단백질을 항원으로 사용하며, 액상 형태로 제공되어 안정적인 단백질 검출에 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:500 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:150 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2D3 |
| Immunogen | Full length human recombinant protein of ACY1 produced in HEK293 cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.29 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2722864 |
Target Information
ACY1 encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group. It is involved in catabolism and salvage of acylated amino acids. The gene is located on chromosome 3p21.1, a region often reduced to homozygosity in small-cell lung cancer (SCLC), where expression may be reduced or undetectable.
The human aminoacylase-1 sequence is highly homologous to the porcine counterpart and represents the first member of a new family of zinc-binding enzymes. Mutations in ACY1 cause aminoacylase-1 deficiency, a metabolic disorder characterized by CNS defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing results in multiple transcript variants, and read-through transcription occurs with the upstream ABHD14A gene. A related pseudogene is located on chromosome 18.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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