Thermo Fisher Scientific GATM Monoclonal Antibody (OTI1E3)

Applications and Tested Dilutions

Product Specifications

Target Information

AGAT, also known as glycine amidinotransferase (L-arginine:glycine amidinotransferase), GATM or transamidinase, is a 423 amino acid protein belonging to the amidinotransferase family. Encoded by a gene located on human chromosome 15q21.1, AGAT exists as three alternatively spliced isoforms and forms a homodimer, with equilibrium favoring the monomeric subunit structure.
AGAT localizes to mitochondrial inner membranes, peripheral membranes, and cytoplasm. It is expressed in placenta, fetal tissues, brain, heart, liver, lung, salivary gland, skeletal muscle, and highly in kidney.
AGAT is elevated in myocardium during heart failure and decreased in IUGR-associated placenta. It catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine, vital for energy metabolism in muscle tissues.
Defects in AGAT are associated with arginine:glycine amidinotransferase deficiency, an autosomal recessive disorder characterized by developmental delay, mental retardation, impaired speech, and depletion of brain creatine/phosphocreatine. AGAT may play roles in embryonic and CNS development, and heart failure response by elevating local creatine synthesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.