Thermo Fisher Scientific LRAT Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Immunogen sequence:
  MKNPMLEVVS LLLEKLLLIS NFTLFSSGAA GEDKGRNSFY ETSSFHRGDV LEVPRTHLTH YGIYLGDNRV AHMMPDILLA LTDDMGRTQK VVSNKRLILG VIVKVASIRV DTVEDFAYGA NILVNHLDES LQKKALLNEE VARRAEKLLG FTPYSLLWNN CEHFVTYCRY GTPISPQSDK FCETVKIIIR DQRS

• Positive Samples: Rat testis

• Cellular Location: Cytoplasm, Endoplasmic reticulum membrane, Endosome, Rough endoplasmic reticulum, Single-pass membrane protein, multivesicular body, perinuclear region

Target Information

Lecithin retinol acyltransferase (LRAT) is a membrane-bound enzyme that catalyzes the transfer of an acyl group from the sn-1 position of lecithin to vitamin A, generating all-trans-retinyl esters (tREs) in the liver and other tissues such as the lung and retinal pigmented epithelium. LRAT also mediates palmitoyl group exchange between RPE65 and tREs, which is critical for the visual pathway. It plays an essential role in vitamin A metabolism, transport, and visual pigment synthesis. LRAT forms homodimers through disulfide bond formation. Loss of LRAT is associated with early-onset severe retinal dystrophy and reduced retinyl ester levels, while decreased expression may be linked to invasive bladder cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.