Thermo Fisher Scientific Phospho-APBB1 (Ser175) Polyclonal Antibody
Phospho-APBB1 (Ser175) 항체로 인간, 마우스, 랫트 시료에 반응. WB, IHC, ICC, ELISA 등 다양한 응용 가능. Rabbit Polyclonal 형식으로 1 mg/mL 농도. Alzheimer’s disease 연구 등에서 유용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:400 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human APBB1 around the phosphorylation site of Ser175 [LS (p-S)PP] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The protein encoded by this gene belongs to the Fe65 protein family and functions as an adaptor protein localized in the nucleus. It interacts with the Alzheimer’s disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1, and the low-density lipoprotein receptor-related protein. APP acts as a cytosolic anchoring site preventing nuclear translocation of this protein. It may play an important role in Alzheimer’s disease pathogenesis by regulating transcription and blocking cell cycle progression through downregulation of thymidylate synthase expression. Multiple alternatively spliced transcript variants have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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