Thermo Fisher Scientific Phospho-APBB1 (Ser347) Polyclonal Antibody
Phospho-APBB1 (Ser347) 단백질을 검출하기 위한 Rabbit Polyclonal 항체. Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합. Human, Mouse, Rat 시료 반응성. Protein A 정제, 1 mg/mL 농도, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human APBB1 around the phosphorylation site of Ser347 [SL (p-S)PE] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The protein encoded by this gene is a member of the Fe65 protein family and functions as an adaptor protein localized in the nucleus. It interacts with Alzheimer’s disease amyloid precursor protein, transcription factor CP2/LSF/LBP1, and the low-density lipoprotein receptor-related protein. APP acts as a cytosolic anchoring site that prevents nuclear translocation of this protein. It may play an important role in the pathogenesis of Alzheimer’s disease by regulating transcription and blocking cell cycle progression through downregulation of thymidylate synthase expression. Multiple alternatively spliced transcript variants have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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