Thermo Fisher Scientific Phospho-alpha Synuclein (Ser129) Recombinant Rabbit Monoclonal Antibody (4G3)
인간 유래 인산화 알파 시뉴클레인(Ser129)을 인식하는 재조합 토끼 단클론 항체입니다. IHC, ICC/IF, ELISA에 적합하며 고순도의 친화 크로마토그래피 정제 제품입니다. 파킨슨병 및 알츠하이머병 연구용으로 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:20–1:200 |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 4G3 |
| Immunogen | A synthesized peptide derived from human Phospho-SNCA (S129) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 3 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_3092630 |
Target Information
Alpha-synuclein is a member of the synuclein family, which includes beta- and gamma-synuclein. These proteins are abundant in the brain and play roles in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein selectively inhibit phospholipase D2, suggesting involvement in signaling pathways.
Mutations in the SNCA gene, encoding alpha-synuclein, are linked to Parkinson’s disease. Alpha-synuclein peptides also form major components of amyloid plaques in Alzheimer’s disease brains. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene.
Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant, and Dementia, Lewy Body.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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