Thermo Fisher Scientific CDK4 Polyclonal Antibody
Human CDK4 단백질에 특이적인 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF, ELISA, IP 등 다양한 응용에 적합. 보존제가 없는 액상 형태이며, 고순도 Protein A 및 항원 친화 크로마토그래피로 정제됨. 세포주기 조절 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:300–1:10,000 |
| ELISA | 1:5,000–1:10,000 |
| Immunoprecipitation (IP) | 1–4 µL/mg of lysate |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Bovine |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human CDK4 Protein (Met1–Glu303) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787776 |
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human CDK4.
Target Information
CDK4/cyclin D3 serine/threonine kinase is a dimeric protein complex. CDK4 is a member of the cyclin-dependent protein kinase family and is involved in the control of cell proliferation during the G1 phase of the cell cycle.
CDK4 forms a complex with D-type cyclins and is inhibited by p16 (cyclin-dependent kinase inhibitor-2). It mediates phosphorylation of the C-terminal region of Rb protein, leading to active transcriptional repression of the E2F complex.
CDC37 and HSP90 preferentially associate with the fraction of CDK4 not bound to D-type cyclins. SMAD3 is a major physiologic substrate of CDK4 and CDK2.
Although CDK6 and CDK4 can both phosphorylate multiple residues in the Rb protein, they exhibit different residue selectivity in vitro; CDK6 phosphorylates Thr821 while CDK4 phosphorylates Thr826.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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