Thermo Fisher Scientific FGF2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Reconstitute in 150 µL of sterile water.
• Centrifuge to remove any insoluble material.
• The peptide is homologous in many other species including mouse and chicken.
• Specificity: FGF2.

Target Information

FGF2 (also known as FGFb, fibroblast growth factor basic) is a member of the fibroblast growth factor (FGF) family. It interacts with high-affinity transmembrane receptors to influence cell proliferation and tissue neovascularization.
FGF2 exists as five isoforms with distinct intracellular localizations and functions. The 18 kDa isoform is predominantly cytosolic and acts through cell surface receptors, whereas the 22, 22.5, 24, and 34 kDa isoforms are nuclear and may signal independently of transmembrane receptor pathways.

In humans, the gene is located on the q arm of chromosome 4. FGF2 is involved in processes such as limb and nervous system development, wound healing, and tumor growth.
The mRNA for FGF2 contains multiple polyadenylation sites and is alternatively translated from non-AUG and AUG initiation codons, resulting in five isoforms with distinct properties.
CUG-initiated isoforms are nuclear and responsible for intracrine effects, while AUG-initiated forms are cytosolic and mediate paracrine/autocrine effects.
FGF2 dysfunction has been associated with Kaposi Sarcoma and corneal neovascularization.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.