Thermo Fisher Scientific CD100 (Semaphorin-4D) Monoclonal Antibody (A8)
CD100(Semaphorin-4D) 단백질을 인식하는 Mouse monoclonal antibody(A8)로, Human, Mouse, Non-human primate에 반응합니다. ICC/IF, Flow Cytometry, Functional Assay에 사용 가능하며 Protein A/G로 정제된 액상 제품입니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
| Functional Assay (Functional) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | A8 |
| Immunogen | PHA stimulated human peripheral blood lymphocytes |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
Semaphorins are neuronal chemorepellants that guide pioneering neurons during nervous system development.
CD100 (also known as Semaphorin 4D) is a 150 kDa homodimer that induces B cell aggregation and enhances their viability in vitro.
It modulates CD40-CD40L B cell signaling by promoting aggregation and survival while downregulating CD23 expression.
CD72 acts as a lymphocyte receptor for CD100, playing a role in B cell signaling regulation.
CD100 is expressed on resting and PHA-stimulated T cells, weakly on NK cells, EBV-transformed B cells, monocytes, and tumor/peripheral blood T cell lines, with higher density on activated T and B cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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