Thermo Fisher Scientific ARTS1 Recombinant Rabbit Monoclonal Antibody (JE52-36)
ARTS1(ERAP1) 단백질을 인식하는 토끼 단클론 항체로 Western blot에 적합. HEK293 세포에서 발현된 재조합 항체이며, Protein A로 정제됨. 1 mg/mL 액상 형태, 4°C 단기 보관 및 -20°C 장기 보관 권장. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JE52-36 |
| Immunogen | Recombinant protein within Human ERAP1 (aa 833–941) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 0.05% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2890277 |
Target Information
The endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) is a 120 kDa protein localized to the lumen of the ER, which removes NH₂-terminal residues from many antigenic precursors for MHC class I peptide presentation. Peptides presented by MHC class I must be 8–11 residues long, and ERAP1 specifically trims peptides of 9 amino acids or more. ERAP1 is also induced by interferon-gamma. The gene encoding human ERAP1 maps to chromosome 5q15.
ERAP1 has also been characterized as:
- A-LAP (Adipocyte-derived leucine aminopeptidase): Inactivates bioactive peptides such as angiotensin II, potentially regulating blood pressure.
- PILS-AP (Puromycin-insensitive leucine-specific aminopeptidase): Plays a role in angiogenesis by regulating proliferation and migration of endothelial cells.
- ARTS-1 (Aminopeptidase regulator of TNFR1 shedding): TNFR1 binding protein that promotes TNFR1 shedding.
Further research is necessary to fully elucidate the functions of this protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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