Thermo Fisher Scientific Pumilio 1 Polyclonal Antibody
Rabbit 유래 Pumilio 1 단클론 항체로 Western blot 및 Immunoprecipitation에 적합. 인간 PUM1 단백질 1-50번 잔기 영역을 면역원으로 사용. 액상 형태, 0.20 mg/mL 농도, 4°C 보관. Mouse 및 Orangutan과 교차 반응 예측.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1 and 50 of Human Pumilio 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with Mouse and Orangutan
Target Information
PUM1 (pumilio homolog 1) is a sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets.
It belongs to the PUF family of evolutionarily conserved RNA-binding proteins.
PUM1 recognizes the Pumilio Response Element (PRE, 5'-UGUANAUA-3'), related to the Nanos Response Element (NRE).
This protein mediates repression via recruitment of the CCR4-POP2-NOT deadenylase complex, leading to translational inhibition and mRNA degradation.
Mutations in PUM1 are associated with spinocerebellar ataxia 47.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: A302-576A-M_PUM1_Q14671-1_Rabbit_PDP.jpeg)
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