Thermo Fisher Scientific Pumilio 1 Polyclonal Antibody
Human Pumilio 1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunoprecipitation에 적합. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태로 제공. 4°C에서 보관하며 연구용으로만 사용 가능.
- 카탈로그번호
- A302577Ax (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Pumilio 1 Polyclonal Antibody
Applications
Western Blot (WB)
- Assay-dependent
Immunoprecipitation (IP)
- 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 200 and 250 of Human Pumilio 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
- Based on 100% sequence identity, this antibody is predicted to react with Mouse and Orangutan.
Target Information
PUM1 (pumilio homolog 1) is a sequence-specific RNA-binding protein acting as a post-transcriptional repressor by binding to the 3′-UTR of mRNA targets.
It belongs to the PUF family of evolutionarily conserved RNA-binding proteins.
PUM1 recognizes the Pumilio Response Element (PRE, 5′-UGUANAUA-3′), related to the Nanos Response Element (NRE).
It mediates repression through recruitment of the CCR4-POP2-NOT deadenylase complex, leading to translational inhibition and mRNA degradation.
Mutations in the PUM1 gene can result in spinocerebellar ataxia 47.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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