Thermo Fisher Scientific YTHDF1 Polyclonal Antibody
YTHDF1 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 ICC/IF에 적합. 인간, 마우스, 랫트 반응성. 1 mg/mL 농도의 액상 제품이며, Affinity chromatography로 정제됨. m6A-함유 mRNA의 번역 효율 조절 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human YTHDF1 (Accession Q9BYJ9), corresponding to amino acid residues M1–Y37 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853804 |
Product Specific Information
Antibody detects endogenous levels of total YTHDF1.
Target Information
YTHDF1 specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting mRNA translation efficiency.
M6A is a modification found at internal sites of mRNAs and some non-coding RNAs, influencing splicing, processing, and stability.
YTHDF1 facilitates ribosome loading to m6A-containing mRNAs and interacts with translation initiation factors eIF3 (EIF3A or EIF3B) to enhance translation initiation.
It plays a role in learning and memory formation in the hippocampus by promoting translation of neuronal mRNAs upon stimulation.
Additionally, it regulates axon guidance via ROBO3 mRNA translation and acts as a negative regulator of antigen cross-presentation in myeloid dendritic cells by enhancing lysosomal degradation and phagosome maturation.
In tumorigenesis, this negative regulation limits anti-tumor responses by reducing tumor-antigen cross-presentation.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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