Thermo Fisher Scientific MEKK3 Polyclonal Antibody
MEKK3 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체. 인간 및 마우스 시료에서 WB와 ICC/IF에 사용 가능. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공. MAPK8 및 ERK 경로 연구에 적합.
- 카탈로그번호
- PA5104501
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MAP3K3 (Accession Q99759), corresponding to amino acid residues V76–N126 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853802 |
Product Specific Information
Antibody detects endogenous levels of total MAP3K3.
Target Information
MAP3K3 (MEKK3) directly regulates MAPK8 and extracellular signal-regulated protein kinase (ERK) pathways by phosphorylating multiple MAP2Ks. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein regulates the stress-activated protein kinase (SAPK) and ERK pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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