Thermo Fisher Scientific Cytochrome P450 1A1/1A2 Monoclonal Antibody (MC1)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-2 µg/mL

-

Immunohistochemistry (PFA fixed) (IHC (PFA))

0.25-0.5 µg/mL

-

Immunocytochemistry (ICC/IF)

2-4 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

MC1

Immunogen

3-methylcholanthrene induced rat cytochrome P450 protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CYP1A1/CYP1A2,uniProtId:P00185-1,ncbiNodeId:10114,antigenRange:1-524,antigenLength:524,antigenImageFileName:1543-MSM1-P1ABX_CYP1A1CYP1A2_P00185-1_House_mouse.svg,antigenImageFileNamePDP:1543-MSM1-P1ABX_CYP1A1CYP1A2_P00185-1_House_mouse_PDP.jpeg,sortOrder:1},{targetFamily:CYP1A1/CYP1A2,uniProtId:P04799-1,ncbiNodeId:10114,antigenRange:1-513,antigenLength:513,antigenImageFileName:1543-MSM1-P1ABX_CYP1A1CYP1A2_P04799-1_House_mouse.svg,antigenImageFileNamePDP:1543-MSM1-P1ABX_CYP1A1CYP1A2_P04799-1_House_mouse_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A/G

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzymes endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3 untranslated region.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.