Thermo Fisher Scientific Cytochrome P450 1A1/1A2 Monoclonal Antibody (MC1)
Cytochrome P450 1A1/1A2 단백질을 인식하는 마우스 단클론 항체로, Western blot, IHC, ICC/IF 등에 사용 가능. 사람, 마우스, 랫드 등 다양한 종에 반응하며, 단백질 A/G로 정제된 액상 형태. 연구용으로 약물 대사 및 효소 발현 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 0.25–0.5 µg/mL |
| Immunocytochemistry (ICC/IF) | 2–4 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MC1 |
| Immunogen | 3-methylcholanthrene induced rat cytochrome P450 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. The encoded protein localizes to the endoplasmic reticulum, and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), including those found in cigarette smoke. Although the endogenous substrate is unknown, the enzyme can metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates include caffeine, aflatoxin B1, and acetaminophen. The transcript contains four Alu sequences flanked by direct repeats in the 3′ untranslated region.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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