Thermo Fisher Scientific CD51/CD61 (Integrin alpha v beta 3) Monoclonal Antibody (23C6), FITC, eBioscience
Human CD51/CD61 (Integrin αvβ3) 인식 단일클론 항체로 FITC 형광 표지. Flow cytometry 및 ICC/IF에 적합하며, melanoma 및 혈액세포 분석에 사용. PBS/BSA buffer에 보관, 4°C 암조건 저장.
- 카탈로그번호
- 11-0519-4x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD51/CD61 (Integrin alpha v beta 3) Monoclonal Antibody (23C6), FITC, eBioscience
Thermo Fisher Scientific CD51/CD61 (Integrin alpha v beta 3) Monoclonal Antibody (23C6), FITC, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunocytochemistry (ICC/IF) | - | View 2 publications |
| Flow Cytometry (Flow) | 5 µL (1 µg)/test | View 10 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), FITC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 23C6 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1907403 |
Product Specific Information
The 23C6 monoclonal antibody reacts with the human CD51/CD61 dimer, also known as integrin αv/β3. CD51 (~120 kDa) can associate with other β subunits (β1, β5, β6) forming receptors for extracellular matrix components. Heterodimers of CD51/CD61 are expressed by melanoma cells, endothelial cells, and osteoclasts, and at low levels by platelets.
The CD51/CD61 complex mediates adhesion to fibrinogen, fibronectin, vitronectin, and thrombospondin.
Applications Reported: Suitable for flow cytometric analysis.
Applications Tested: Pre-titrated and tested on human melanoma and peripheral blood cells at 5 µL (1 µg) per test.
A test is defined as the antibody amount that stains cells in 100 µL volume (typically 10⁵–10⁸ cells/test).
Excitation: 488 nm; Emission: 520 nm; Laser: Blue.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
CD51 (αV) and CD61 (β3) integrins form a complex binding vitronectin at the RGD sequence. The complex also binds fibrinogen, von Willebrand factor, thrombospondin, fibronectin, osteopontin, and collagen. Reacts with osteoclasts, placenta, melanoma cell lines, and weakly with platelets.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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