Thermo Fisher Scientific SHOX Polyclonal Antibody
SHOX 단백질을 인식하는 Rabbit Polyclonal 항체로, WB와 IHC에 적합합니다. 인체 시료에 반응하며, 합성 펩타이드를 면역원으로 제작되었습니다. 동결건조 형태로 제공되며, 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | – |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | – |
| Miscellaneous PubMed (Misc) | – | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide to the internal region of human SHOX conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: SHOX
Target Information
Homeodomain proteins (HP) are transcriptional regulators that coordinate the expression of genes involved in development, differentiation, and cellular transformation. HPs are characterized by a conserved domain of 60 amino acid residues that recognize and bind regulatory regions of target genes.
SHOX, a member of the bicoid subfamily of the paired homeobox family, controls growth and developmental processes and undergoes splicing to produce two isoforms, SHOXA and SHOXB.
- SHOXA: Expressed in skeletal muscle, placenta, pancreas, heart, bone marrow fibroblast, and to a lesser extent in kidney and lung.
- SHOXB: Highly expressed in osteogenic cells, not expressed in brain, kidney, liver, or lung.
Mutations in the SHOX gene cause Leri-Weill dyschondrosteosis (LWD) and Langer mesomelic dysplasia (LMD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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