Thermo Fisher Scientific SLC39A4 Polyclonal Antibody
SLC39A4 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC에 적합. 인간 및 흰쥐 반응성 확인. 동결건조 형태로 제공되며 장기보관 시 -20°C 권장. 연구용으로 사용 가능하며 ZIP4 관련 암 연구에 활용 가능.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from human SLC39A4 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: SLC39A4.
Target Information
The zinc transporter ZIP4, also known as SLC39A4, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in growth, development, and differentiation. ZIP4 was initially identified as a zinc-uptake transporter in the intestine and as a candidate gene for acrodermatitis enteropathica (AE), a rare inherited defect in the absorption of dietary zinc. Aberrant expression of ZIP4 has been linked to cancer progression and aggressiveness, particularly in pancreatic cancer. ZIP4 expression is also activated in hepatocellular carcinoma, where it represses apoptosis, enhances cell cycle progression, and increases migration, suggesting a role in multiple cancer types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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