Thermo Fisher Scientific Alpha A Crystallin Polyclonal Antibody
Alpha A Crystallin 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 실험에 적합합니다. Human, Mouse, Rat에 반응하며, 액상 형태(1 mg/mL)로 제공됩니다. Lens 단백질 연구 및 스트레스 반응 관련 단백질 분석에 활용됩니다.
- 카탈로그번호
- PA5118901
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CRYAA (Accession P02489), corresponding to amino acid residues S41–D91 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903401 |
Product Specific Information
Antibody detects endogenous levels of total HspB4.
Target Information
Lens proteins consist almost entirely of crystallins (about 95%), which are also found in vertebrate skeletal muscle tissue.
In the lens, crystallins maintain the proper refractive index. Mammalian lens contains three major classes: alpha, beta, and gamma crystallins.
Alpha-crystallin is the largest, composed of two primary gene products—alpha-A and alpha-B.
Alpha-crystallin comprises about 40% of total lens protein and acts as a chaperone to prevent aggregation that may lead to cataract formation.
Phosphorylated states of alpha-crystallin occur in response to cellular stress, contributing to structural control and protein maintenance.
Alpha-B crystallin has been linked to Alexander’s disease, where it accumulates in brain cells of affected individuals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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