Thermo Fisher Scientific HSD3B1 Monoclonal Antibody (FDO66Q)
HSD3B1 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, Western blot, IHC(P/F), ICC/IF 등에 사용 가능. 다양한 종에 반응하며, Protein G로 정제된 액상 형태. 단기 4℃, 장기 -20℃ 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC-P) | 10–20 µg/mL |
| Immunohistochemistry (Frozen) (IHC-F) | 10–20 µg/mL |
| Immunocytochemistry (ICC/IF) | 10–20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Baboon, Bovine, Goat, Human, Mouse, Non-human primate, Sheep, Pig, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | FDO66Q |
| Immunogen | JEG Choriocarcinoma cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | TBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2120102 |
Product Specific Information
- Suggested positive control: human placental villi, antigen standard for HSD3B1 (transient overexpression lysate).
Target Information
Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer’s disease. Abeta peptide is 40–43 amino acids long and generated from the beta-amyloid precursor protein (beta APP) in a two-step process.
The first step involves cleavage of the extracellular, amino-terminal domain of beta APP by beta-secretase (BACE), followed by further processing by gamma-secretase, a multi-subunit complex containing presenilin-1 and -2.
Abeta is an extracellular filamentous protein component of amyloid cores, neuritic plaques, and deposits in neurofibrillary tangles.
Abnormal accumulation of beta amyloid is a hallmark of Alzheimer’s disease, as well as Lewy body dementia, Down’s syndrome, amyloidosis (Dutch type), cerebral amyloid angiopathy, and the Guam Parkinson-Dementia complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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