Thermo Fisher Scientific HIF1A Monoclonal Antibody (H1alpha67), Biotin
HIF1A 단백질을 인식하는 Biotin 결합 단클론 항체로, Western blot, IHC, ICC 등 다양한 응용에 적합합니다. 인간 및 다양한 종에 반응하며, 단백질 A로 정제된 고순도 제품입니다. 저산소 반응 및 세포 대사 연구에 유용합니다.
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Thermo Fisher Scientific HIF1A Monoclonal Antibody (H1alpha67), Biotin
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500 | View 8 publications |
| Immunohistochemistry (IHC) | - | View 22 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:300 | - |
| Immunocytochemistry (ICC/IF) | Assay-Dependent | View 1 publication |
| Flow Cytometry (Flow) | Assay-Dependent | - |
| ELISA | Assay-Dependent | - |
| Gel Shift (GS) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Avian, Bovine, Dog, Ferret, Human, Mouse, Non-human primate, Sheep, Pig, Rabbit, Rat |
| Published Species | Human, Mouse, Rabbit, Rat |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | H1alpha67 |
| Immunogen | Fusion protein containing amino acids 432–528 of human HIF-1α |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.94 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1957709 |
Additional Formats
Product Specific Information
In Western blot, multiple bands may be seen at 100–120 kDa representing post-translational modification of HIF-1α.
For WB, testing on nuclear extracts is recommended.
Target Information
HIF1-alpha (HIF1A) is a subunit of HIF1, a transcription factor found in mammalian cells under reduced oxygen tension. HIF-1 is a heterodimer consisting of alpha and beta subunits, both belonging to the basic-helix-loop-helix PAS family of transcription factors.
HIF1 functions as a transcriptional regulator of the adaptive response to hypoxia, activating transcription of genes that increase oxygen delivery or facilitate metabolic adaptation. These include erythropoietin, glucose transporters, glycolytic enzymes, VEGF, and others.
HIF1-alpha regulates hypoxia-mediated apoptosis, cell proliferation, and tumor angiogenesis. It interacts with p53 under hypoxic conditions, influencing ubiquitination and degradation. Induction of NOX4 by HIF1-alpha contributes to ROS maintenance and proliferation after hypoxia.
In humans, HIF1A is located on chromosome 14q and binds to p300, forming complexes that activate hypoxia-responsive genes. Hypoxia plays a key role in diseases such as ischemia, cancer, pulmonary hypertension, and COPD.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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배송/결제/교환/반품 안내
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