Thermo Fisher Scientific Calponin-1 Recombinant Rabbit Monoclonal Antibody (CNN1, 1408R)
Calponin-1 단백질을 표적으로 하는 재조합 토끼 단클론 항체로, IHC, ICC/IF, Flow Cytometry에 사용 가능. 인간 및 랫트 반응성. HEK293 세포 발현, Protein A/G 정제, 액상 형태로 제공. 연구용으로만 사용.
- 카탈로그번호
- 1264-RBM4-P1ABX
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | CNN1, 1408R |
| Immunogen | Recombinant human full-length CNN1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Immunohistochemistry (PFA fixed): incubate antibody for 30 minutes at room temperature (RT).
Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at RT for 20 minutes.
Target Information
Calponin is a thin filament-associated protein involved in the regulation and modulation of smooth muscle contraction. It binds to actin, calmodulin, troponin C, and tropomyosin.
Calponin is expressed in smooth muscle and tissues containing significant amounts of smooth muscle. Two isoforms exist: 34 kDa and 29 kDa. The 29 kDa form is primarily found in urogenital tract muscle.
Calponin expression has also been observed in myoepithelial cells from benign and malignant breast lesions. It stains smooth muscle, myoepithelial cells, myofibroblasts, keratinocytes, and nerve fibers.
It identifies myoepithelial cells in breast lesions and helps differentiate breast collagenous spherulosis (positive) from adenoid cystic carcinoma. Adenoid cystic carcinoma in salivary gland tumors is calponin positive.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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