Thermo Fisher Scientific ITFG2 Polyclonal Antibody
Human ITFG2 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:50–1:200 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관. KICSTOR 복합체 관련 mTORC1 신호 조절 연구에 적합.
- 카탈로그번호
- PA558485
- 판매단위
- pk
카탈로그
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Applications
Tested Application
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ITFG2. Recombinant protein control fragment (Product # RP-102844) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642809 |
Product Specific Information
Immunogen sequence:
KVLDASGHHE TLIGEEQRPV FKQHIPANTK VMLISDIDGD GCRELVVGYT DRVVRAFRWE ELGEGPEHLT GQLVSLKKWM LEGQVDSLSV TLGPL
Sequence identity:
- Mouse: 94%
- Rat: 93%
Target Information
As part of the KICSTOR complex, ITFG2 functions in the amino acid-sensing branch of the TORC1 signaling pathway. It recruits the GATOR1 complex to lysosomal membranes and mediates its interaction with GATOR2 and RAG GTPases. ITFG2 acts upstream of the RAG GTPases and negatively regulates mTORC1 signaling in the absence of amino acids. Without the KICSTOR complex, mTORC1 remains constitutively localized to the lysosome and activated. The complex may also play a role in mTORC1 regulation by glucose.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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