Thermo Fisher Scientific GABBR1 Polyclonal Antibody
GABBR1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 최적화되어 있습니다. Human 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며, 1 mg/mL 농도와 0.02% sodium azide를 포함합니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide containing residues 33–54 of GABBR1 (UniProt ID: Q9UBS5-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2263244 |
Product Specific Information
- Suggested positive control: MDA-MB-231, human brain protein.
Target Information
Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulate phospholipase A2, activate potassium channels, inactivate voltage-dependent calcium channels, and modulate inositol phospholipid hydrolysis.
Plays a critical role in fine-tuning inhibitory synaptic transmission.
Pre-synaptic GABA-B receptors inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B receptors decrease neuronal excitability by activating inwardly rectifying potassium (Kir) conductance.
Also implicated in synaptic inhibition, hippocampal long-term potentiation, slow wave sleep, muscle relaxation, and antinociception.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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