Thermo Fisher Scientific MAdCAM1 Monoclonal Antibody (CA102.2C1), eBioscience
Human MAdCAM-1을 인식하는 Mouse Monoclonal Antibody로, ELISA, WB, Functional Assay에 적합. 단백질 A로 정제된 액상형 항체이며, PBS buffer에 보존제 없이 4°C에서 보관. 점막 림프조직 관련 연구 및 세포 부착 분자 분석에 활용 가능.
- 카탈로그번호
- BMS170
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-Dependent | View 1 publication |
| ELISA | Assay-Dependent | - |
| Functional Assay | Assay-Dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CA102.2C1 |
| Immunogen | Recombinant Human MadCAM-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10596496 |
Product Specific Information
This antigen is expressed in mucosal lymphoid tissue and lamina propria, serving as a counter-receptor for CD62L and CD49d.
MAdCAM-1 plays a crucial role in homing of memory T cells to the gut lamina propria and in recirculation of naive lymphocytes within Peyer’s patches and mesenteric lymph nodes.
Applications tested include ELISA, Functional Studies (Blocking), and Western Blotting.
Target Information
The encoded protein is an endothelial cell adhesion molecule that interacts preferentially with leukocyte beta7 integrin LPAM-1 (α4β7), L-selectin, and VLA-4 (α4β1) on myeloid cells, directing leukocytes into mucosal and inflamed tissues.
It belongs to the immunoglobulin family and is structurally related to ICAM1 and VCAM1.
At least seven alternatively spliced transcripts encoding different isoforms have been identified, though the full-length nature of some variants remains undetermined.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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