Thermo Fisher Scientific RET Proto-oncogene Monoclonal Antibody (RET/2976)
RET 단백질을 인식하는 Mouse Monoclonal Antibody로, 인간 시료 반응성 확인됨. ELISA 및 Peptide Array 등 다양한 응용 가능. 단백질 A/G로 정제된 액상 형태이며, 4°C에서 안정적으로 보관. RET 관련 종양 및 신경계 연구에 적합.
- 카탈로그번호
- 5979-MSM6-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific RET Proto-oncogene Monoclonal Antibody (RET/2976)
Thermo Fisher Scientific RET Proto-oncogene Monoclonal Antibody (RET/2976)
Applications
- ELISA (ELISA): Assay-dependent
- Peptide Array (Array): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | RET/2976 |
| Immunogen | Recombinant fragment (around aa 702–848) of human RET protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody is stable for 24 months.
- Positive Control: Breast, Prostate or Colon Carcinoma
- Cellular Localization: Cytoplasmic, Cell Surface and Nuclear
- Specificity Comments:
The RET proto-oncogene is structurally related to tyrosine kinase transmembrane receptors and is involved in GDNF signaling. RET expression is reported in several regions of the central nervous system, including developing cranial nerve ganglia, dorsal root ganglia subsets, motor neurons in spinal cord and hindbrain, neuro-retina, and renal collecting duct tips in developing kidney.
Alterations in the RET gene are associated with diseases such as papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma, and Hirschsprung’s disease.
Target Information
The receptor tyrosine kinase RET is a member of the cadherin superfamily and plays a crucial role in neural crest development. RET can undergo oncogenic activation via cytogenetic rearrangement and transduces signals for cell growth and differentiation.
Mutations in the RET gene are associated with multiple endocrine neoplasia (type IIA and IIB), Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found, with additional variants of uncertain biological validity.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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