
Thermo Fisher Scientific RET Proto-oncogene Monoclonal Antibody (RET/7690)
RET 단백질을 인식하는 마우스 단클론 항체로, IHC(P)에서 1–2 µg/mL 농도로 사용 가능. 인간 조직 반응성 검증 완료. 세포막, 세포질, 핵에서 RET 발현 검출에 적합. 단백질 A/G 정제, 4°C 보관.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | RET/7690 |
| Immunogen | Recombinant fragment (around aa 702–848) of human RET protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Human breast, prostate, or colon carcinoma
- Cellular Location: Cytoplasm, Cell Surface, Nucleus
Target Information
The receptor tyrosine kinase RET is a member of the cadherin superfamily. RET plays a crucial role in neural crest development and can undergo oncogenic activation by cytogenetic rearrangement. It transduces signals for cell growth and differentiation.
Mutations in the RET gene are associated with multiple endocrine neoplasia type IIA and IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been identified, with additional variants of uncertain biological validity.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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