Thermo Fisher Scientific NR0B2 Monoclonal Antibody (OTI7B5)
NR0B2 단백질을 타겟으로 하는 Thermo Fisher Scientific의 단클론 항체로, Western blot 및 IHC(Paraffin)에 최적화됨. Mouse IgG2a 형식, 액상 형태로 제공되며 -20°C에서 보관. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): 1:2,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7B5 |
| Immunogen | Full length human recombinant protein of NR0B2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724863 |
Target Information
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. It belongs to the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones. Some members of this family are orphan nuclear receptors without known ligands.
This protein interacts with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. It also interacts with estrogen receptors, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two mechanisms: competition with coactivators and direct transcriptional repression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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