Thermo Fisher Scientific NR0B2 Monoclonal Antibody (OTI5F10)
Human NR0B2 단백질을 인식하는 Mouse IgG2a 단클론 항체로, WB 및 IHC(P) 실험에 적합합니다. 1 mg/mL 농도의 액상 형태이며, PBS/BSA/glycerol buffer에 보존됩니다. 연구용으로 핵수용체 관련 전사조절 연구에 활용 가능합니다.
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Applications
- Western Blot (WB): 1:2,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5F10 |
| Immunogen | Full length human recombinant protein of NR0B2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724862 |
Target Information
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, some of which are orphan nuclear receptors without known ligands.
This protein interacts with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. It also interacts with estrogen receptors, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two mechanisms: competition with coactivators and direct transcriptional repression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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