Thermo Fisher Scientific P23 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
• Based on 100% sequence identity, this antibody is predicted to react with Rat, Chicken, Bovine, and Orangutan.

Target Information

Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Prior to activation, steroid receptors associate with various proteins in both stable and transient complexes. These include heat shock proteins (HSP70, HSP90), immunophilins (FKBP52, FKBP54, CyP-40), and other proteins such as p23, p60, and p48.

p23, along with HSP70, HSP90, and p60, forms a transient intermediate complex with the progesterone receptor (PR). Cloned human p23 encodes a 160-amino-acid protein highly conserved between species, with no homology to previously identified proteins. It is a highly acidic phosphoprotein containing an aspartic acid-rich C-terminal domain and multiple potential phosphorylation sites. In vitro studies suggest that p23 binds to HSP90 and is necessary for the interaction of HSP90 and CyP-40 with PR. Though its exact function remains unclear, p23 is considered an important factor in PR function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.