Thermo Fisher Scientific P23 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
• Based on 100% sequence identity, this antibody is predicted to react with Rat, Chicken, Bovine, and Orangutan

Target Information

Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Prior to activation, steroid receptors associate with various proteins in both stable and transient complexes. These include heat shock proteins (HSP70, HSP90), immunophilins (FKBP52, FKBP54, CyP-40), and other proteins termed p23, p60, and p48.

p23, together with HSP70, HSP90, and p60, forms part of a transient intermediate complex with the progesterone receptor (PR). The cloned human p23 encodes a 160-amino-acid protein, highly conserved across species, with no homology to previously identified proteins. It is a highly acidic phosphoprotein containing an aspartic acid-rich C-terminal domain and multiple potential phosphorylation sites.

In vitro studies suggest that p23 binds to HSP90 and is necessary for the binding of HSP90 and CyP-40 to PR. Although its exact function and mechanism remain unclear, p23 appears to play an important role in PR function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음 — OCR 텍스트만 통합됨)