Thermo Fisher Scientific MST1 (STK4) Polyclonal Antibody
Thermo Fisher Scientific의 MST1 (STK4) Polyclonal Antibody는 인간 STK4/MST1 단백질을 특이적으로 인식하는 토끼 IgG 폴리클로날 항체입니다. Western blot, IHC, ELISA, IP에 사용 가능하며, Hippo 신호 경로 연구에 적합합니다. 보존제 무첨가 제품으로 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,500–1:10,000 |
| ELISA | 1:5,000–1:10,000 |
| Immunoprecipitation (IP) | 0.2–1 µL/mg of lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human STK4/MST1 protein (Glu2–Phe487) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Lot-Specific |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 1 month. For long-term storage, store at -20°C. |
| Shipping Conditions | Wet ice |
| RRID | AB_2788299 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human STK4/MST1.
Target Information
STK4 (MST1) is a serine/threonine kinase involved in apoptosis and chromatin condensation. It is a stress-activated, pro-apoptotic kinase that, after caspase cleavage, enters the nucleus to induce chromatin condensation and DNA fragmentation.
STK4 is a key component of the Hippo signaling pathway, which regulates organ size and tumor suppression by restricting proliferation and promoting apoptosis. The pathway involves a kinase cascade where STK3/MST2 and STK4/MST1 activate LATS1/2, leading to phosphorylation and inactivation of YAP1 and WWTR1/TAZ, thereby controlling cell proliferation, death, and migration.
STK4/MST1 and STK3/MST2 are essential for repressing hepatocyte proliferation, preventing activation of adult liver stem cells, and inhibiting tumor formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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