Thermo Fisher Scientific HIF1A Monoclonal Antibody (ESEE122), Biotin
HIF1A 단백질을 인식하는 ESEE122 클론의 Biotin 결합 단일클론 항체. Western blot, IHC, ICC, Flow 등 다양한 응용 가능. 인간, 마우스, 랫, 개, 소 반응성. 고순도 Protein G 정제, PBS 버퍼 및 sodium azide 포함. 연구용으로만 사용.
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Thermo Fisher Scientific HIF1A Monoclonal Antibody (ESEE122), Biotin
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:5,000 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:5,000 |
| Immunocytochemistry (ICC/IF) | Assay-Dependent |
| Flow Cytometry (Flow) | Assay-Dependent |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Bovine, Dog, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ESEE122 |
| Immunogen | Human HIF-1 alpha amino acids 329–530 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.96 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153095 |
Additional Formats
Product Specific Information
Suggested positive control: Cos7 CoCl₂-treated nuclear extract.
Target Information
HIF1-alpha (HIF1A) is a subunit of HIF1, a transcription factor found in mammalian cells under reduced oxygen tension. HIF-1 is a heterodimer consisting of alpha and beta subunits, both belonging to the basic-helix-loop-helix Per-aryl hydrocarbon receptor nuclear translocator-Sim (PAS) family.
HIF1 functions as a transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, HIF-1 activates transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, VEGF, and other genes that enhance oxygen delivery or metabolic adaptation.
HIF1-alpha regulates hypoxia-mediated apoptosis, cell proliferation, and tumor angiogenesis. It interacts with p53 and MDM2 pathways affecting protein degradation under hypoxia. Induction of NOX4 by HIF1-alpha contributes to maintaining ROS levels and hypoxia-induced proliferation.
In humans, HIF1A is located on chromosome 14q. The C-terminal of HIF1A binds to p300, forming complexes that induce hypoxia-responsive genes such as VEGF. Hypoxia plays a role in diseases including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease, and COPD.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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배송/결제/교환/반품 안내
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