Thermo Fisher Scientific HIF1A Monoclonal Antibody (ESEE122), Biotin

Thermo Fisher Scientific HIF1A Monoclonal Antibody (ESEE122), Biotin

Applications and Tested Dilution

Product Specifications

Additional Formats

• Unconjugated
• DyLight 488
• HRP
• Request custom conjugation

Product Specific Information

Suggested positive control: Cos7 CoCl₂-treated nuclear extract.

Target Information

HIF1-alpha (HIF1A) is a subunit of HIF1, a transcription factor found in mammalian cells under reduced oxygen tension. HIF-1 is a heterodimer consisting of alpha and beta subunits, both belonging to the basic-helix-loop-helix Per-aryl hydrocarbon receptor nuclear translocator-Sim (PAS) family.
HIF1 functions as a transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, HIF-1 activates transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, VEGF, and other genes that enhance oxygen delivery or metabolic adaptation.
HIF1-alpha regulates hypoxia-mediated apoptosis, cell proliferation, and tumor angiogenesis. It interacts with p53 and MDM2 pathways affecting protein degradation under hypoxia. Induction of NOX4 by HIF1-alpha contributes to maintaining ROS levels and hypoxia-induced proliferation.
In humans, HIF1A is located on chromosome 14q. The C-terminal of HIF1A binds to p300, forming complexes that induce hypoxia-responsive genes such as VEGF. Hypoxia plays a role in diseases including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease, and COPD.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(해당 상품 관련 이미지는 이 섹션에 배치됩니다.)