Thermo Fisher Scientific RTN1 Monoclonal Antibody (RNL-3)
RTN1 단백질을 검출하는 Thermo Fisher Scientific의 RNL-3 모노클로날 항체로, Western blot, IHC, ICC/IF, Flow cytometry에 사용 가능. 인간, 비인간 영장류, 토끼 반응성. 1 mg/mL 농도의 액상 항체로, 신경내분비 조직 연구에 적합.
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- MA106814
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:200 |
| Flow Cytometry (Flow) | 1:100–1:200 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Non-human primate, Rabbit |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | RNL-3 |
| Immunogen | Small cell lung cancer cell line NCI-H82 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Purified |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_561125 |
Product Specific Information
MA1-06814 detects reticulon-1A (NSP-A) and reticulon-1B (NSP-B) in human, rabbit, and non-human primate cells.
It has been successfully used in Western blotting, immunocytochemistry, FACS, and immunohistochemistry (paraffin) procedures.
In Western blot, it detects a ~135 kDa band representing reticulon-1A and a ~45 kDa band representing reticulon-1B.
The immunogen is derived from the small cell lung cancer cell line NCI-H82.
Target Information
Reticulon-1 (formerly NSP, Neuroendocrine-Specific Protein) is specifically expressed in neural and neuroendocrine tissues.
The NSP gene is located on human chromosome 14q21–q22 and encodes three overlapping proteins: reticulon-1A (NSP-A), reticulon-1B (NSP-B), and reticulon-1C (NSP-C).
These proteins are anchored to endoplasmic reticulum membranes via their common C-terminal regions.
- Reticulon-1A: ~135 kDa, occurs in various isoforms depending on serine phosphorylation; a reliable marker for neuroendocrine differentiation in lung cancer diagnosis.
- Reticulon-1B: ~45 kDa phosphoprotein, restricted to the lung cancer cell line NCI-H82; not found in human tissues.
- Reticulon-1C: ~23 kDa, non-phosphorylated; found with Reticulon-1A in small cell lung carcinoma (SCLC) cell lines, not in non-SCLC cultures.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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