Thermo Fisher Scientific Phospho-CREB (Ser133) Polyclonal Antibody
Phospho-CREB (Ser133)에 특이적인 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC에 적합하며, 다양한 종에서 반응 예측. Ser133 인산화 CREB 검출용으로 높은 특이성과 재현성 제공.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunohistochemistry (IHC) | 1:100–1:1,000 | - |
Product Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser133 of rat CREB1 conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2230004 |
Product Specific Information
- Predicted to react with bovine, canine, chicken, human, mouse, non-human primate, rat, sheep, Xenopus, and zebrafish based on 100% sequence homology.
- Specific for the ~45 kDa CREB phosphorylated at Ser133 in Western blots of rat brain lysates.
- Immunolabeling can be blocked by lambda-phosphatase treatment.
Target Information
CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to various extracellular signals such as neurotransmitters, hormones, membrane depolarization, and growth factors.
Activation of CREB depends on phosphorylation at serine 133 via MAP kinase pathways (p44/42, p90RSK, p38 MAPK, MSK1).
Phosphorylated CREB is the active transcription factor form, interacting with CREB binding protein (CBP) at serine 133.
CREB is involved in circadian rhythm regulation, adipocyte differentiation, and learning and memory.
In humans, the gene is located on chromosome 2q.
Dysfunction of CREB is linked to Alzheimer’s disease, histiocytoma, and soft tissue melanoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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