Thermo Fisher Scientific ANTXR2 Polyclonal Antibody
Thermo Fisher Scientific의 ANTXR2 폴리클로날 항체는 인간 Anthrax Toxin Receptor 2(CMG2)를 인식하는 Rabbit IgG 항체입니다. Western blot과 IHC(P) 실험에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.01–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–20 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein Anthrax Toxin Receptor 2 (amino acids 34–318 of the target protein) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903453 |
Target Information
Anthrax toxin receptor 2 (ATR2), also known as capillary morphogenesis gene 2 (CMG2), acts as a cellular receptor for anthrax toxin. ATR2/CMG2 is a type I membrane protein containing an extracellular von Willebrand factor A (VWA) domain with a metal ion-dependent adhesion site (MIDAS) motif. It binds to protective antigen (PA), one of the three monomeric proteins released as anthrax toxin from Bacillus anthracis. Once bound, PA facilitates the delivery of edema factor (EF) and lethal factor (LF) into the cytosol. Mutations in ATR2/CMG2 can inhibit binding by the VWA domain, leading to infantile systemic hyalinosis (ISH) and juvenile hyaline fibromatosis (JHF), which are rare stiff-skin syndromes characterized by hyaline deposition in various organs, particularly the skin and gingiva.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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