Thermo Fisher Scientific APOB Polyclonal Antibody
Thermo Fisher Scientific의 APOB Polyclonal Antibody는 Rat에 반응하는 Rabbit IgG 기반 항체로 Western blot 및 IHC(P) 실험에 적합합니다. Recombinant Apolipoprotein B(aa 3329-3494)를 면역원으로 사용하며, 고순도의 항원 친화 크로마토그래피로 정제되어 있습니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.5–2 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 5–20 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein Apolipoprotein B (aa 3329–3494 of the target protein) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903458 |
Target Information
Apolipoprotein B (apo B) in human plasma is a major protein of low-density lipoproteins (LDL) with a molecular mass of approximately 260–500 kDa. Apo B binds to specific receptors on cell membranes and is involved in removal of LDL and very low-density lipoprotein (VLDL) cholesterol from circulation.
LDL mediates the uptake and clearance of cholesterol from the blood. In atherosclerotic lesions, oxidatively modified LDL is recognized and ingested by macrophages via scavenger receptor A and CD36.
Apolipoprotein B is synthesized mainly in the liver and is a major component of VLDL, IDL, LDL, and lipoprotein(a). It serves as a ligand for the LDL receptor, and elevated levels are associated with premature atherosclerosis.
Two isoforms, apoB-48 and apoB-100, are produced from a single gene through RNA editing. Mutations in the Apolipoprotein B gene can lead to disorders such as hypobetalipoproteinemia and hypercholesterolemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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