Thermo Fisher Scientific Phospho-beta Catenin (Ser552) Polyclonal Antibody
인간, 마우스, 랫트에 반응하는 Phospho-beta Catenin (Ser552) 폴리클로날 항체. Western blot 및 ELISA에 사용 가능하며, 항원 친화 크로마토그래피로 정제됨. PBS 기반 저장용액에 50% 글리세롤 포함. -20°C 보관 권장.
- 카탈로그번호
- PA540304
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1:40,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human Catenin-beta around the phosphorylation site of S552 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2608156 |
Product Specific Information
This antibody is predicted to react with human and rat based on sequence homology.
Target Information
Beta-catenin is an adherens junction (AJ) protein originally identified as a component of cell-cell adhesion structures. AJs are essential for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. Beta-catenin interacts with the cytoplasmic domain of E-cadherin and links it to alpha-catenin, anchoring the E-cadherin complex to the cortical actin cytoskeleton.
It also associates with cytoskeletal complexes containing adenomatous polyposis coli protein and microtubules, participating in signaling pathways involving tyrosine kinases, phosphatases, and Wnt/Wingless.
Beta-catenin is expressed in hair follicle cells and various epithelial tissues and is implicated in tumorigenesis of several cancers, including colorectal, ovarian, and skin cancers. In the nucleus, it co-activates Lef/Tcf transcription factors, promoting transcription of proliferation-related genes such as cyclin D and c-myc.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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