Thermo Fisher Scientific TNNT1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000
• Publications: References

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:1,000
• Publications: References

Product Specifications

Product Specific Information

• Recommended positive controls: H1299, Porcine skeletal muscle
• Predicted reactivity: Mouse (90%), Rat (90%), Pig (91%), Bovine (91%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

This gene encodes a protein that is a subunit of troponin, a regulatory complex located on the thin filament of the sarcomere. The complex regulates striated muscle contraction in response to intracellular calcium concentration changes and consists of three subunits:

• Troponin C: binds calcium
• Troponin T: binds tropomyosin
• Troponin I: inhibitory subunit

This protein represents the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5 (Amish nemaline myopathy), a neuromuscular disorder characterized by muscle weakness and rod-shaped inclusions in skeletal muscle fibers, typically fatal in infancy due to respiratory insufficiency. Multiple transcript variants encoding different isoforms have been identified.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.