Thermo Fisher Scientific MUTYH Polyclonal Antibody
MUTYH 단백질을 표적으로 하는 Thermo Fisher Scientific의 rabbit polyclonal 항체입니다. Western blot, IHC, ICC/IF에 사용 가능하며 인간, 마우스, 랫트 반응성을 가집니다. 고순도(>95%) 항원 친화 크로마토그래피 정제, 장기 보관 시 -20°C 권장.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific MUTYH Polyclonal Antibody
Thermo Fisher Scientific MUTYH Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length Human MUTYH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719778 |
Product Specific Information
This antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is >95% (by SDS-PAGE).
Target Information
MYH (mutY homolog (E. coli)) is a DNA glycosylase mismatch repair enzyme that, in conjunction with mutM (OGG1), cleaves adenine residues paired with oxidized (8-hydroxyguanine) or non-modified guanine to correct A/G and A/C mismatches.
DNA glycosylases initiate repair by cleaving N-glycosyl bonds to start base excision repair. MYH is crucial for avoiding mutations from oxidative DNA damage. Multiple N-terminal splice variants exist in mammalian cells. Elevated MYH levels in A549 cells exposed to oxygen and infrared radiation improve cell survival.
Biallelic MYH germ-line mutations predispose humans to colorectal adenomas and carcinomas. MYH is abundant in neurons, maintaining mitochondrial genome integrity against reactive oxygen species (ROS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
- PA5-76050_MUTYH_Q9UIF7-1_Rabbit.svg
- PA5-76050_MUTYH_Q9UIF7-1_Rabbit_PDP.jpeg
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.