Thermo Fisher Scientific NEDD4 Monoclonal Antibody (OTI7A1), TrueMAB
Human NEDD4 단백질(aa 160–460)에 특이적인 Mouse Monoclonal Antibody (Clone OTI7A1). Western blot에 최적화된 TrueMAB 형식. 고순도 Affinity chromatography로 정제되어 있으며, 안정적 PBS/BSA/glycerol buffer에 보관. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): Tested dilution 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7A1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 160–460 of human NEDD4 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The E3 ubiquitin-protein ligase NEDD4 is a Ubl conjugation pathway protein containing one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and four WW domains.
It is involved in VEGFR-2/KDFR degradation independently of its ubiquitin-ligase activity and acts as a potential proto-oncogene that negatively regulates PTEN via ubiquitination, analogous to Mdm2 and p53.
NEDD4 also participates in viral budding and regulates epithelial Na⁺ channels, contributing to arterial hypertension.
It localizes to the sarcolemmal region of muscle fibers, where increased expression leads to muscle unloading and denervation, along with decreased Notch1 expression — acting as a downregulator of Notch-1 gene expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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